In these studies, the primary outcome measure was menstrual blood loss (MBL), measured using the alkaline hematin method. Cyklokapron kan i enkelte tilfælde give kvalme, mavesmerter eller diarre. In some female dogs, the presence of inflammatory exudate over the bulbar conjunctival mucosa was observed. Inform patients that they should immediately stop Cyklokapron tablets if they notice any eye symptoms or change in their vision. This study compared the effects of two doses of Cyklokapron tablets (1950 mg and 3900 mg given daily for up to 5 days during each menstrual period) versus placebo on MBL over a 3-cycle treatment duration. AUCtldc = area under the drug concentration curve from time 0 to time of last determinable concentration, AUCinf = area under the drug concentration curve from time 0 to infinity, a AUC0-tau (mcg-h/mL) = area under the drug concentration curve from time 0 to 8 hours. Concomitant therapy with tissue plasminogen activators may decrease the efficacy of both Cyklokapron tablets and tissue plasminogen activators. This patient information leaflet summarizes the most important information about Cyklokapron tablets. (2.2, 8.6). Is it expensive? Cerebral edema and cerebral infarction may be caused by use of Cyklokapron tablets in women with subarachnoid hemorrhage. Cyklokapron tablets are not indicated for use in pregnant women. Cyklokapron tablets may be administered without regard to meals. On average, subjects had a history of HMB for approximately 10 years and 40% had fibroids as determined by transvaginal ultrasound. Behandlingen kan gentages med 1-4 timers mellemrum. The dose and duration of this medicine is decided by the type of disease for which it is prescribed. Do not give Cyklokapron tablets to other people, even if they have the same symptoms that you have. Your privacy is guaranteed. India's only LegitScript and ISO/ IEC 27001 certified online healthcare platform. Call your healthcare provider for medical advice about side effects. The effect of hepatic impairment on the disposition of Cyklokapron tablets has not been evaluated. Can I take Cyklokapron 500mg Injection for more than 5 days? It's advisable to consult your doctor on time for a proper recommendation and medical consultations. Therefore, exercise caution if a patient taking Cyklokapron tablets therapy requires tissue plasminogen activators [see Drug Interactions ( 7.2 ) ]. There are no adequate and well-controlled studies in pregnant women [see Use in Specific Populations ( 8.1 )]. En brusetablet på 1 gram opløses i koldt eller lunkent vand (ca. Din mail må derfor ikke indeholde personfølsomme oplysninger. Excretion of Cyklokapron is about 90% at 24 hours after intravenous administration of 10 mg/kg. The Cmax and AUC values after a single oral dose of 1300 mg in the adolescent females were 20 to 25% less than those in the adult females given the same dose in a separate study. No, Cyklokapron 500mg Injection does not affect fertility. Especially tell your healthcare provider if you take: Ask your healthcare provider if you are not sure if your medicine is one that is described above. Usually, the benefits of the medicine are greater than the risk of side effects. Cyklokapron is present in the mother’s milk at a concentration of about one hundredth of the corresponding serum concentrations. Because Cyklokapron tablets are antifibrinolytic, concomitant use of hormonal contraception and Cyklokapron tablets may further exacerbate the increased thrombotic risk associated with combination hormonal contraceptives. Was ist Cyklokapron-Injektionslösung und wofür wird sie angewendet? Although plasmin may be formed by conformational changes in plasminogen, binding to and dissolution of the fibrin matrix is inhibited. Derzeit liegen nur be- Cyklokapron 500mg Injection promotes blood clotting and can rarely cause blood clot to travel to the lungs (pulmonary embolism) which can turn fatal sometimes. In a 9-month toxicology study, dogs were administered Cyklokapron in food at doses of 0, 200, 600, or 1200 mg/kg/day. Plasma clearance of Cyklokapron is 110 to 116 mL/min. The recommended dose of CYKLOKAPRON is 10 mg/kg actual body weight intravenously administered as a single dose, immediately before tooth extractions Infuse no more than 1 mL/minute to avoid hypotension [see Warnings and Precautions (5.1)].Following tooth extraction, CYKLOKAPRON may be administered for 2 to 8 days at a dose of 10 mg/kg actual body weight 3 to 4 times . The recommended dose of Cyklokapron tablets for women with normal renal function is two 650 mg tablets taken three times daily (3900 mg/day) for a maximum of 5 days during monthly menstruation. [2] [4] It is taken either orally or by injection into a vein. Cyklokapron is present in the mother’s milk at a concentration of about one hundredth of the corresponding serum concentration. In the presence of Cyklokapron, the lysine receptor binding sites of plasmin for fibrin are occupied, preventing binding to fibrin monomers, thus preserving and stabilizing fibrin’s matrix structure. Consult doctors online from the comfort of your home for free. In patients with renal impairment, the plasma concentration of Cyklokapron increased as serum creatinine concentration increased [see Clinical Pharmacology ( 12.3 )]. Andre kan stoppe, når blødningen ophører. Women using hormonal contraception were excluded from the study. Patients should be instructed to report visual and ocular symptoms promptly. Common side effects include: nausea, vomiting, diarrhea; dizziness, feeling light-headed; mild itching or rash . The following adverse reactions have been identified from postmarketing experience with Cyklokapron. The inactive ingredients contained in each tablet are: colloidal silicon dioxide, copovidone, crospovidone, eudragit, glyceryl behenate, lactose monohydrate, hypromellose, magnesium stearate, microcrystalline cellulose, polyethylene glycol, talc, and triethyl citrate. No specific information is available on the treatment of overdose with Cyklokapron tablets. Du må ikke tage Cyklokapron tabletter, hvis du har synligt blod i urinen. Jedoch sind für diese Indikationen nur begrenzt Daten zur Wirksamkeit, Dosierung und Sicherheit ver-fügbar. known to have any of the following conditions: Active thromboembolic disease (e.g., deep vein thrombosis, pulmonary embolism, or cerebral thrombosis), A history of thrombosis or thromboembolism, including retinal vein or artery occlusion, An intrinsic risk of thrombosis or thromboembolism (e.g., thrombogenic valvular disease, thrombogenic cardiac rhythm disease, or hypercoagulopathy), Concomitant use of Cyklokapron tablets with Factor IX complex concentrates, anti-inhibitor coagulant concentrates or all-trans retinoic acid may increase the risk of thrombosis. Following a single 10 mg/kg intravenous injection of Cyklokapron in 28 patients, the 24-hour urinary fractions of Cyklokapron with serum creatinine concentrations 1.4 to 2.8, 2.8 to 5.7, and greater than 5.7 mg/dL were 51, 39, and 19%, respectively. Es wird auf Verschreibung des Arztes oder der Ärztin verwendet, um gynäkologische oder geburtshilfliche Blutungen zu normalisieren, wie z.B. Cyklokapron 500 MG Injection . What should I tell my healthcare provider before taking t ranexamic acid tablets ? . Cyklokapron tablets do not contain any hormones. Take Cyklokapron tablets exactly as your healthcare provider tells you. The conjunctivitis resolved following cessation of the drug. These are not all of the possible side effects of Cyklokapron tablets. An embryo-fetal developmental toxicity study in rats and a perinatal developmental toxicity study in rats were conducted using Cyklokapron. Lad vattet sidde lidt, men lad det ikke tørre ud. Frequently asked questions about Tranexamic Acid. Do not take Cyklokapron tablets until your period has started. However, there have been US postmarketing reports of venous and arterial thrombotic events in women who have used Cyklokapron tablets concomitantly with combination hormonal contraceptives. In other studies, focal areas of retinal degeneration were observed in cats, dogs and rats following oral or intravenous Cyklokapron doses at 6 to 40 times the recommended usual human dose based on mg/m2 (actual animal doses between 250 to 1600 mg/kg/day). Abnormal uterine bleeding in VTE patients treated with rivaroxaban compared to vitamin K antagonists. Blood clots. Therefore, exercise caution when prescribing Cyklokapron tablets to patients with acute promyelocytic leukemia taking all-trans retinoic acid [see Warnings and Precautions ( 5.1 ) and Drug Interactions ( 7.4 )]. dk kan du også finde indlægssedler for de fleste lægemidler. Figure 1 - The efficacy of Cyklokapron tablets 3900 mg/day over 3 menstrual cycles and over 6 menstrual cycles was demonstrated versus placebo in the double-blind, placebo-controlled efficacy studies. Dr. Boonyawat and colleagues cover key points with respect to definition and etiology of HMB: 1) The term menorrhagia has been discarded and replaced with heavy menstrual bleeding (HMB); 2) in a clinically meaningful way, HMB is defined as menstrual blood loss that interferes with a woman's physical, social, emotional, and/or material quality of life; 3) HMB associated with anticoagulant use . There was no significant increase in the corrected QT interval at any time up to 24 hours after the administration of either dose of Cyklokapron tablets. Urinary excretion following a single intravenous injection of Cyklokapron declines as renal function decreases. It is used in the treatment of uncontrollable bleeding conditions that are seen after tooth extraction, in menstruation, haemorrhage (the release of blood from a broken blood vessel), angioedema (painless swelling under the skin), etc. Cyklokapron is 3% bound to plasma proteins with no apparent binding to albumin. To report SUSPECTED ADVERSE REACTIONS, contact Actavis at 1-800-272-5525 or FDA at 1-800-FDA-1088 or www.fda.gov/medwatch. Vaginal bleeding and heavy menstrual bleeding during direct oral anti-Xa inhibitor therapy. For this reason, concomitant use of Cyklokapron tablets with combination hormonal contraceptives is contraindicated [see Contraindications (4) and Warnings and Precautions ( 5.1 )]. Auch können Blutverluste bei Blutungen im Magen-Darm-Trakt und Nachblutungen nach Operationen beträchtlich gemindert werden. HEMOSTATICS Type: Rx Drug CYKLOKAPRON (TRANEXAMIC ACID): This medication is used to treat heavy bleeding during your menstrual period. Finally, tranexamic acid can be considered. Tranexamic acid, otherwise known by it's trade name Cyklokapron, is an antifibrinolytic agent which helps blood to clot and therefore can be used in the short term for the treatment of heavy . Cyklokapron tablets should be used during lactation only if clearly needed. The chemical name is trans-4-aminomethyl-cyclohexanecarboxylic acid. For more information, ask your healthcare provider or pharmacist. This is of particular concern in women who are obese or smoke cigarettes, especially smokers over 35 years of age. Når tabletten er helt opløst, skylles munden med opløsningen. Hence, regular eye check should be done during treatment and doctor should be informed if you notice any change in your vision. For this reason, concomitant use of Cyklokapron tablets with combination hormonal contraceptives is contraindicated. Cyklokapron kann allein oder zusammen mit anderen Medikamenten angewendet werden. Actual daily dose in mice was up to 5000 mg/kg/day in food. If you miss a dose, take it when you remember, and then take your next dose at least six hours later. doi: https://doi.org/10.1182/hem.V15.3.8467. General information about t ranexamic acid tablets. Die Wirksamkeit, Dosierung und Si-cherheit von Tranexamsäure bei Herzope-rationen an Kindern wurden noch nicht umfassend geklärt. One study compared the effects of two doses of Cyklokapron tablets (1950 mg and 3900 mg given daily for up to 5 days during each menstrual period) versus placebo over a 3-cycle treatment duration. Yes, Cyklokapron 500mg Injection promotes blood clotting, thereby preventing blood loss. Cyklokapron tablets are provided as white to off-white, oval-shaped, film coated tablets. The active ingredient in each tablet is 650 mg Cyklokapron. Read the Patient Information that comes with Cyklokapron tablets before you start using the drug and each time you get a refill. Progestin intrauterine devices (IUDs) can be used safely, and combined estrogen-progestin contraceptives are treatment options as long as reliable and full-dose anticoagulation is given. Cyklokapron tablets are indicated for women of reproductive age and are not intended for use by postmenopausal women. Beipackzettel und wichtige Informationen zum Medikament CYKLOKAPRON Filmtabletten: Wirkung, Anwendung, Gegenanzeigen, Nebenwirkungen, Dosierung, Anwendungshinweise . Cyklokapron tablets may be taken with or without food. Long-term safety of Cyklokapron tablets was studied in two open-label studies. After a single oral administration of two 650 mg tablets of Cyklokapron tablets, the peak plasma concentration occurred at approximately 3 hours (Tmax). Allergic reaction. Cyklokapron tablets are a prescription medicine used to treat your heavy monthly period (menstruation) when your bleeding gets in the way of social, leisure and physical activities. For at kunne sende din besked, mangler du at give dit samtykke. Det kan hjælpe at tage en lidt mindre dosis efter aftale med lægen. The total exposure to 3900 mg/day Cyklokapron tablets in this study was 1,956 cycles. Heavy menstrual bleeding (HMB) is a well-known adverse effect of anticoagulant therapy. Cyklokapron er et lægemiddel, der anvendes til at standse eller forebygge blødning. What are the possible side effects of t ranexamic acid tablets ? Cyklokapron 500 MG Injection is an anti-fibrinolytic medicine (a medicine used for clotting of blood) containing Tranexamic acid. Does Cyklokapron 500mg Injection affect fertility? Got a health query? A total of 781 subjects were enrolled and 239 completed the study through 27 menstrual cycles. Can Cyklokapron 500mg Injection be taken for nose bleeding? In both studies, subjects were generally healthy women who had menstrual blood loss of ≥ 80 mL. Q. En brusetablet på 1 gram opløses i koldt eller lunkent vand (ca. Was sollten Sie vor der Anwendung von Cyklokapron-Injektionslösung beachten? The efficacy of Cyklokapron tablets 3900 mg/day over 3 menstrual cycles and over 6 menstrual cycles was demonstrated versus placebo in the double-blind, placebo-controlled efficacy studies (see Figure 1). Inform patients that they should stop Cyklokapron tablets and seek immediate medical attention if they notice symptoms of a severe allergic reaction (e.g., shortness of breath or throat tightening). Eye changes. Although many research studies have shown that the increased risk of clot can be due to some other additional factors rather than Cyklokapron 500mg Injection itself. Therefore, this medicine is not a type of contraceptive medicine and it will not affect your chances of becoming pregnant. Abnormal vaginal bleeding in women with venous thromboembolism treated with apixaban or warfarin. Immediately discontinue use if visual or ocular symptoms occur. A total of 288 subjects were enrolled and 196 subjects completed the study through 9 menstrual cycles. Tranexamic Acid is an anti-fibrinolytic. The mean plasma pharmacokinetic parameters of Cyklokapron determined in 19 healthy women following a single (two 650 mg tablets) and multiple (two 650 mg tablets three times daily for 5 days) oral dose of Cyklokapron tablets are shown in Table 3. In a rat embryo-fetal developmental toxicity study, Cyklokapron had no adverse effects on embryo-fetal development when administered during the period of organogenesis (from gestation days 6 through 17) at doses 1, 2 and 4 times the recommended human oral dose of 3900 mg/day. Subjects received (1) Cyklokapron tablets 1300 mg (two 650 mg tablets), (2) Cyklokapron tablets 3900 mg (six 650 mg tablets; three times the recommended single dose), (3) moxifloxacin 400 mg, and (4) placebo. The molecular formula is C8H15N02 and the molecular weight is 157.2. In healthy subjects, Cyklokapron at blood concentrations less than 10 mg/mL has no effect on the platelet count, the coagulation time or various coagulation factors in whole blood or citrated blood. A list of adverse events occurring in ≥ 5% of subjects and more frequently in Cyklokapron tablets treated subjects receiving 3900 mg/day compared to placebo is provided in Table 2. b Nasal and sinus symptoms include nasal, respiratory tract and sinus congestion, sinusitis, acute sinusitis, sinus headache, allergic sinusitis and sinus pain, and multiple allergies and seasonal allergies, c Abdominal pain includes abdominal tenderness and discomfort, d Musculoskeletal pain includes musculoskeletal discomfort and myalgia, e Arthralgia includes joint stiffness and swelling. 2 cl). Addictive Medicine is categorically called Controlled substances by the government. Venous and arterial thrombosis or thromboembolism, as well as cases of retinal artery and retinal vein occlusions, have been reported with Cyklokapron. Af hensyn til miljøet må du ikke smide medicinrester i afløbet, toilettet eller skraldespanden. Menstrual bleeding patterns in women treated with rivaroxaban: Data from the EINSTEIN CHOICE trial. b Positive means reflect an improvement from baseline, d Responders are defined as subjects who experienced a reduction from baseline in frequency of large stains. Our experts create high-quality content about medicines, diseases, lab investigations, Over-The-Counter (OTC) health products, Ayurvedic herbs/ingredients, and alternative remedies. Do not take more than two tablets at a time to make up for missed doses. Following multiple oral doses (two 650 mg tablets three times daily) administration of Cyklokapron tablets for 5 days, the mean Cmax increased by approximately 19% and the mean area under the plasma concentration-time curve (AUC) remained unchanged, compared to a single oral dose administration (two 650 mg tablets). Hyperplastic, but not neoplastic, lesions were reported at lower doses. Every medicine has its own side effects and these side effects are unlikely to happen if taken as directed. Store Cyklokapron tablets at room temperature between 20º to 25º C (68º to 77º F). It is freely soluble in water and in glacial acetic acid and is very slightly soluble in ethanol and practically insoluble in ether. Cyklokapron is known to cross the placenta and appears in cord blood at concentrations approximately equal to maternal concentration. Do not use Cyklokapron tablets for a condition for which it was not prescribed. Cyklokapron Filmtabletten enthalten ein Arzneimittel zur Behandlung und Vorbeugung von Blutungen infolge gesteigerter Auflösung von Blutgerinnseln (Hyperfibrinolyse). All products displayed on Tata 1mg are procured from verified and licensed pharmacies. Concomitant Use of Hormonal Contraceptives. The time between the start of your periods is less than 21 days or more than 35 days, Birth control pills or other hormonal birth control, Medicines used to help your blood form clots. The effect of Cyklokapron tablets on QT interval was evaluated in a randomized, single-dose, 4-way crossover study in 48 healthy females aged 18 to 49 years. Management and outcomes of vaginal bleeding and heavy menstrual bleeding in women of reproductive age on oral anti-factor Xa inhibitor therapy: a case series. For more information, go to www.actavis.com or call 1-800-272-5525. Q. Når blodet størkner (koagulerer) for at standse en blødning, vil det normalt blive opløst igen for at skabe fri blodgennemstrømning, efterhånden som såret heler. Erfahren Sie alles rund um Cyklokapron-Injektionslösung: Wirkung, Anwendungsgebiete, Dosierung, Nebenwirkungen, Wechselwirkungen, ähnliche Medikamente u.v.m. Cyklokapron is usually given just before the dental procedure, and daily for up to 8 days afterward. 2 cl). CYKLOKAPRON Tablets are used to prevent excessive bleeding in patients with: traumatic hyphaema (bleeding into the front part of the eye) blood clotting disorders, who are having minor surgery . For heavy bleeding during monthly menstruation, it is usually taken for up to 5 days. Can Cyklokapron 500mg Injection affect the colour vision of eyes? A case of anaphylactic shock has also been reported in the literature, involving a patient who received an intravenous bolus of Cyklokapron. Cyklokapron ist ein verschreibungspflichtiges Arzneimittel zur Vorbeugung von Blutungen im Zusammenhang mit der Zahnextraktion bei Patienten mit Hämophilie. Tranexamic acid is not a hormone. However, cases of overdose of Cyklokapron have been reported. Carcinogenicity studies with Cyklokapron in male mice at doses as high as 6 times the recommended human dose of 3900 mg/day showed an increased incidence of leukemia which may have been related to treatment. Most elimination post intravenous administration occurred during the first 10 hours, giving an apparent elimination half-life of approximately 2 hours. Do not prescribe Cyklokapron tablets to women who are. 38 63 38 63, https://www.rigshospitalet.dk/kontakt/Sider/e-mail.aspx. No drug-drug interaction studies were conducted with Cyklokapron tablets. Cyklokapron tablets are an antifibrinolytic indicated for the treatment of cyclic heavy menstrual bleeding. Of the 187 evaluable subjects, 115 Cyklokapron tablets subjects and 72 placebo subjects took at least one dose of study drug and had post-treatment data available. [2] [3] It is also used for hereditary angioedema. The Hematologist 2018; 15 (3): No Pagination Specified. Of the 294 evaluable subjects, 115 Cyklokapron tablets 1950 mg/day subjects, 112 Cyklokapron tablets 3900 mg/day subjects and 67 placebo subjects took at least one dose of study drug and had post-treatment data available. No, Cyklokapron 500mg Injection does not affect fertility. Can Cyklokapron 500mg Injection be given or injected into muscles? Side Effects of Cyklokapron are Musculoskeletal (bone, muscle or joint) pain, Joint pain, Headache, Back pain, Vomiting, Nausea, Abdominal pain, Fatigue, Diarrhea, Hypotension (low blood pressure), Sinus disorder, Nasal discomfort, Muscle cramp, Migraine, Anemia (low number of red blood cells), Allergic dermatitis, Lightheadedness, Thromboembolism. Q. You are breastfeeding or plan to breastfeed. Menorrhagia, or heavy menstrual bleeding, is defined as 80 mL or more of menstrual blood loss per period, although in practice the diagnosis is based on patient report of an amount or. However, Cyklokapron is known to cross the placenta and appears in cord blood at concentrations approximately equal to the maternal concentration. Your doctor will refer you to an eye doctor who will examine your eyes. Cyklokapron, however, at blood concentrations of 1 and 10 mg/mL prolongs the thrombin time. Aftal dette med lægen. Are using a form of birth control that contains estrogen and a progestin (like a birth control pill, patch, or vaginal ring). Patienter med svær blødersygdom bør fortsætte med mundskylning i en uge efter indgrebet. Effect of food: Cyklokapron tablets may be administered without regard to meals. No adverse effects were observed in either study at doses up to 4 times the recommended human oral dose of 3900 mg/day based on mg/m2 (actual animal dose 1500 mg/kg/day). Seven percent (7%) of all subjects were of Hispanic origin. A case of severe allergic reaction to Cyklokapron tablets was reported in the clinical trials, involving a subject who experienced dyspnea, tightening of her throat, and facial flushing that required emergency medical treatment. Jeg giver hermed samtykke til, at Region Hovedstaden behandler oplysningerne i min henvendelse. Beyer-Westendorf J, Michalski F, Tittl L, et al. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. A case of severe allergic reaction to Cyklokapron tablets was reported in the extension trial, involving a subject on her fourth cycle of treatment, who experienced dyspnea, tightening of her throat, and facial flushing that required emergency medical treatment. . e Non-significant difference versus placebo. Cyklokapron tablets and other medicines can affect each other, causing side effects. Overskydende medicin kan afleveres til Afdeling for Blodsygdomme eller på apoteket. Vom Gynäkologen verschrieben. Har du nedsat nyrefunktion, skal dosis nedsættes. Subjects were 18 to 49 years of age with a mean age of approximately 40 years, had cyclic menses every 21 to 35 days, and a BMI of approximately 32 kg/m2. It belongs to a class of drugs known as antifibrinolytics. In a study involving 28 patients with acute promyelocytic leukemia who were given either orally administered all-trans retinoic acid plus intravenously administered Cyklokapron, all-trans retinoic acid plus chemotherapy, or all-trans retinoic acid plus Cyklokapron plus chemotherapy, all 4 patients who were given all-trans retinoic acid plus Cyklokapron died, with 3 of the 4 deaths due to thrombotic complications. We do not process requests for Schedule X and habit forming drugs. *Insufficient data exist and there is no consensus amongst thrombosis and abnormal uterine bleeding experts in respect to the optimal anticoagulant drug in women with heavy menstrual bleeding on anticoagulation.1 Analyses of some of the phase III DOAC versus warfarin venous thromboembolism clinical trials and observational studies have not clearly identified one direct oral anticoagulant to lead to less heavy bleeding than another.2,5-10. Information last updated by Dr. Varun Gupta, MD Pharmacology on 7th Jun 2022. The information was verified by Dr. Rachana Salvi, MD Pharmacology. The phase IV clinical study analyzes which people take Cyklokapron and have Heavy or prolong menstrual bleeding. It should be given strictly through slow injection into the veins to prevent side effects. What is in this leaflet: 1. Recommended Dosage The recommended dose of CYKLOKAPRON is 10 mg/kg actual body weight intravenously administered as a single dose, immediately before tooth extractions Infuse no more than 1 mL/minute to avoid hypotension [see Warnings and Precautions (5.1)]. Cyklokapron tablets are not for women who have already gone through menopause (post-menopausal). Cyklokapron gehört zu einer Klasse von Arzneimitteln, die als Antifibrinolytika bezeichnet werden. Cyklokapron tablets also statistically significantly reduced limitations on social, leisure, and physical activities in the 3900 mg/day dose group compared to placebo (see Table 5). Wenn Sie eine größere Menge Filmtabletten eingenommen haben, als Sie sollten: Can you take Cyklokapron 500mg Injection on an empty stomach? Results are shown in Table 4. If you have severe shortness of breath and your throat feels tight, stop taking Cyklokapron tablets and get medical care right away. Study success also required achieving a reduction in MBL that was determined to be clinically meaningful to the subjects. However, in rare cases, this can lead to a chance of developing a clot in the deep leg veins, a condition known as deep vein thrombosis (DVT). The mean terminal half-life of Cyklokapron tablets is approximately 11 hours. Die Blutungen haben während der Menstruation deutlich nachgelassen. Hyperplasia of the biliary tract and cholangioma and adenocarcinoma of the intrahepatic biliary system have been reported in one strain of rats after dietary administration of doses exceeding the maximum tolerated dose for 22 months. d Responders are defined as subjects who experienced a reduction from baseline in frequency of large stains.