Jg., Nr. MFH contributed to the abstract and wrote the conclusion. J Clin Lab Anal. 2014;58 https://doi.org/10.3402/fnr.v58.21796. Auch die Aussagekraft des Tests auf 25-OH-D3 hat zwar ihre Grenzen, auf die wir weiter unten eingehen werden – er bleibt aber der beste Einzeltest, der derzeit zur Verfügung steht und ist zurecht der Standard in der Diagnose eines Vitamin-D-Mangels. ISSN 0954-3007 (print), https://doi.org/10.1038/s41430-019-0553-3, Comparing derivatization reagents for quantitative LC–MS/MS analysis of a variety of vitamin D metabolites, Threshold of 25(OH)D and consequently adjusted parathyroid hormone reference intervals: data mining for relationship between vitamin D and parathyroid hormone, Vitamin D status in chimpanzees in human care: a Europe wide study, https://www.accessdata.fda.gov/cdrh_docs/reviews/K071480.pdf, http://www.ifcc.org/ifcc-scientific-division/sd-committees/c-bm/, The clinical relevance of native vitamin D in pediatric kidney disease, Towards harmonization of directly measured free 25-hydroxyvitamin D using an enzyme-linked immunosorbent assay. Maturitas. 2009;12:236–43. Vitamin D deficiency and insufficiency has become a pandemic health problem with a consequent increase of requests for determining circulating levels of 25-hydroxyvitamin D [25(OH)D]. 2011;96:53–8. Um den aktuellen Vitamin-D-Spiegel und die nötige einzunehmende Dosis eines entsprechenden Präparates zu ermitteln, sollte eine Blutuntersuchung beim Arzt vorgenommen werden. However, the analytical performance of these immunoassays, including radioimmunoassay and ELISA, is highly variable, and even mass spectrometric methods, which nowadays serves as the gold standard for the quantitatively determination of 25(OH)D, do not necessarily produce comparable results, creating limitations for the definition of normal vitamin D status ranges. 24,25-Dihydroxyvitamin d3 and vitamin D status of community-dwelling black and white Americans. Wie ist bei schlechten Testergebnissen vorzugehen? Rude RK, Adams JS, Ryzen E, Endres DB, Niimi H, Horst RL, Haddad JG Jr, Singer FR. Nur wenn der Arzt den begründeten Verdacht auf einen Vitamin-D-Mangel diagnostiziert, übernehmen die Kassen die Kosten. Annweiler C, Riou J, Alessandri A, Gicquel D, Henni S, Feart C, et al. Die wenigsten denken allerdings daran, einmal ihren Vitamin-D-Wert beim Hausarzt untersuchen zu lassen. Kidney Int, 1987, 31. 2012;82:412–6. Finde jetzt heraus wie das Sonnenvitamin auf Psyche, Knochen & co. wirkt. CYP24A1 mutations in a cohort of hypercalcemic patients: evidence for a recessive trait. Annweiler C, Kabeshova A, Callens A, Paty ML, Duval GT, Holick MF. Eyles D, Anderson C, Ko P, Jones A, Thomas A, Burne T, et al. J Steroid Biochem Mol Biol. Diabetes Metab Syndr Obes. Give your physician a call if you are unsure whether at-home or in-lab testing is right for you. Vitamin D: 7 Wirkungen, die du spüren & sehen kannst! Neben den gänigen Bluttests beim Arzt gibt es mittlerweile recht komfortable Test-Kits für zuhause, die momentan die wohl bequemste Variante darstellen, einen Vitamin-D-Test durchzuführen. 2015;87:7964–70. After taking the test, you’ll have access to a team of nurses 24/7. 2015;16:536 e8–19. Molin A, Baudoin R, Kaufmann M, Souberbielle JC, Ryckewaert A, Vantyghem MC, et al. Clin Biochem. 80-150 nmol/l. Thank you, {{form.email}}, for signing up. 2009 Nov;1(6):300-6. doi: 10.4161/derm.1.6.10970, Michael F. Holick, Vitamin D Status: Measurement, Interpretation, and Clinical Application, Annals of Epidemiology, Volume 19, Issue 2, February 2009, Pages 73-78, ISSN 1047-2797. Ⓒ 2023 Dotdash Media, Inc. — All rights reserved, Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Dowling KG, Hull G, Sundvall J, Lamberg-Allardt C, Cashman KD. How accurate are assays for 25-hydroxyvitamin D? Open Access articles citing this article. Von den Messwerten her ist dieser Fall selbst in kombinierter Messung nicht von einem echten Vitamin-D-Mangel zu unterscheiden, da sich exakt das selbe Muster zeigt.Dieser Fall offenbart sich meist erst dadurch, dass die Blutwerte trotz Vitamin-D-Substitution oder ausreichender Sonnenexposition nicht ansteigen. Google Scholar. PubMed “A key point here is that we do not know what an optimal levels of vitamin D is for combatting COVID-19,” Hewison tells Verywell. Steven A. Abrams, MD, a pediatrics professor at the University of Texas at Austin Dell Medical School, says many people are outside less due to the pandemic, so taking a routine supplement “isn’t a bad idea.”. An at-home test is a convenient way to monitor your vitamin D levels. Low vitamin D levels have also been associated with poorer cognitive function in older adults, although the effects of vitamin D supplementation on cognition aren’t yet clear (9). Vitamin-D-Unterversorgung in Deutschland. Heath AK, Williamson EJ, Ebeling PR, Kvaskoff D, Eyles DW, English DR. Measurements of 25-hydroxyvitamin D concentrations in archived dried blood spots are reliable and accurately reflect those in plasma. 2013;59:885–91. Quantitation of 25-hydroxyvitamin D in dried blood spots by 2D LC-MS/MS without derivatization and correlation with serum in adult and pediatric studies. Mit den richtigen Präparaten, Lebensmitteln und Sonnenbädern gelingt es! Garg U. 2017;9:E658. Hsu SA, Soldo J, Gupta M. Evaluation of two automated immunoassays for 25-OH vitamin D: comparison against LC-MS/MS. Was kosten sie? Li L, Zeng Q, Yuan J, Xie Z. Bosworth CR, Levin G, Robinson-Cohen C, Hoofnagle AN, Ruzinski J, Young B, et al. (6). „Wir empfehlen eine Beratung durch den Arzt oder Apotheker, bevor man zu Vitaminpräparaten greift. Detection of 1,25-dihydroxyvitamin D in human serum using receptor assisted chemiluminescent hormone assay technology. Clin Biochem. Cost-benefit analysis of calcium and vitamin D supplements. Am J Clin Nutr. Contact a healthcare professional if you are concerned about your vitamin D levels. Vitamin-D-Test: Eine wichtige Vorsorgeuntersuchung 2015;30:1119–33. Evaluation of a new generation automated assay for 25-hydroxy vitamin D based on competitive protein binding. Verywell Health's content is for informational and educational purposes only. However, user error is always a possibility with at-home tests. Fuleihan Gel H, Bouillon R, Clarke B, Chakhtoura M, Cooper C, McClung M, et al. Low serum concentrations of 1,25-dihydroxyvitamin D in human magnesium deficiency. Vitamin D in adults: update on testing and supplementation. Key Takeaways Vitamin D deficiency has been linked to COVID-19. Vitamin D is not found naturally in many foods, but it is essential to healthy bones and a properly functioning immune system, among other things. Moreover, we also suggest the use of alternatives to blood test, including standardized surveys that may be of value in alerting health-care professionals about the vitamin D status of their patients. And, given the importance of vitamin D for musculoskeletal health, heart health, your immune system, and even cancer prevention, this is worth paying attention to. In the meantime, to ensure continued support, we are displaying the site without styles 2019;187:130–3. Wieviel Vitamin D brauche ich? If you have a known bone disorder or a problem absorbing calcium, a vitamin D test may be used to see if a lack of vitamin D is causing your condition. Taking a multivitamin with vitamin D may help improve bone health. “The home tests are fine, although they seem like a lot of trouble compared to just taking a supplement,” he says. It’s worth noting that a true vitamin D deficiency (blood levels below 12 ng/mL) is much less common, particularly in the United States, where many foods like milk and cereal are fortified with vitamin D. But many adults do have lower than optimal vitamin D levels. Während bei einem hohen Spiegel an 25-OH-D3 von einer guten Versorgung ausgegangen werden kann und bei einem niedrigen Wert von einem Mangel, ist dies beim Vitamin-D-Hormon nicht unbedingt der Fall, da es nach Bedarf produziert wird. J Nutr Health Aging. Vitamin D Test: Wie kann man Vitamin D testen? Immer mehr Ärzte teilen mittlerweile die Ansicht, dass eine regelmäßige Überprüfung der Vitamin-D-Werte durch einen Vitamin-D-Test als wichtige Vorsorgeuntersuchung etabliert werden sollte. Muscogiuri G, Barrea L, Altieri B, Di Somma C, Bhattoa H, Laudisio D, et al. If you buy through links on this page, we may earn a small commission Here’s our process. Wird bereits hier ein Mangel festgestellt, ist die Vitamin-D-Versorgung als absolut kritisch einzuschätzen. 2017;100:1323–7. Nur ein Vitamin-D-Test kann hier wirklich Aufschluss geben. 2018;38:439–53. Nur mit einem Vitamin-D-Test kann die Versorgung sicher beurteilt werden. 2014;99:3319–24. Analysis of vitamin D metabolic markers by mass spectrometry: current techniques, limitations of the “gold standard” method, and anticipated future directions. Formiga F, Ferrer A, Almeda J, San Jose A, Gil A, Pujol R. Utility of geriatric assessment tools to identify 85-years old subjects with vitamin D deficiency. Hollis BW, Kamerud JQ, Selvaag SR, Lorenz JD, Napoli JL. The American journal of clinical nutrition, 2008, 88. 2017;91:97–107. Dermatoendocrinology. Decision summary. Establishing an accuracy basis for the Vitamin D External Quality Assessment Scheme (DEQAS). 2012;58:531–42. 2015;61:627–35. Note that there isn’t much research available on the benefits of screening for vitamin D deficiency. Holick MF. But given the margin for error, it may be best to have your blood drawn at a lab facility by a certified lab technician. Effect of calcifediol treatment and best available therapy versus best available therapy on intensive care unit admission and mortality among patients hospitalized for COVID-19: A pilot randomized clinical study. 2016;46:645–53. J Steroid Biochem Mol Biol. 2019;190:224–33. Clin Chem Lab Med. This is a detailed article about vitamin D and its health effects. Deschasaux M, Souberbielle JC, Andreeva VA, Sutton A, Charnaux N, Kesse-Guyot E, et al. Grant WB, Moukayed M. Vitamin D3 from ultraviolet-B exposure or oral intake in relation to cancer incidence and mortality. 2016;9:11–6. External quality assessment of 24, 25-dihydroxyvitamin D3 (24, 25(OH)2D3) assays. Am J Clin Nutr. Kipshoven, Christoph. Vitamin D Mangel schnell beheben? Vitamin D deficiency is more common than too much vitamin D, however (2). Clin Biochem. Querschnittsstudie zur Abschätzung des Vitamin-D-Status in der Bevölkerung in Deutschland (DEVID-Studie). Natürlich kannst du deinen Vitamin D Spiegel wie gewohnt bei deinem Hausarzt, deiner Hausärztin mittels Bluttest checken lassen. Bei der Schildrüsenerkrankung Primärer Hyperparathyreoidismus etwa wird krankheitsbedingt die Umwandlung von 25-OH-D3 zu Calcitriol stark nach oben reguliert. Schuld sei in vielen Fällen eine Unterversorgung mit Vitamin D. „Etwa 80 Prozent aller in Deutschland Lebenden weisen im Winter einen schlechten Vitamin-D-Wert auf“, weiß Richard Klämbt, Präsident der Apothekerkammer Bremen. These groups may include: “Depending on the company you purchase from, you'll experience similar [testing] practices to that of a traditional lab you would visit in-person,” she says. 2017;18:273–83. Makowski AJ, Rathmacher JA, Horst RL, Sempos CT. Simplified 25-hydroxyvitamin D standardization and optimization in dried blood spots by LC-MS/MS. PubMed PMID: 18689389. Clinical laboratory, 2005, 52. A 25-hydroxy vitamin D test is a test that measures the amount of 25-OH vitamin D in your blood. (3) Daher ist bei Unsicherheit über den eigenen Vitamin-D-Status grundsätzlich allen Menschen zu einem Vitamin-D-Test zu raten – es ist die einzige Möglichkeit, verlässlich festzustellen, wie es um die Vitamin-D-Versorgung bestellt ist. Surveillance evaluation of the standardization of assay values for serum total 25-hydroxyvitamin D concentration in Japan. A rapid and simple liquid-chromatography-tandem mass spectrometry method for measuring 25-hydroxyvitamin D2 and 25-hydroxyvitamin D3 in human serum: comparison with two automated immunoassays. Einfach ausgedrückt wird durch die Vitamin-D-Regulation gesteuert, wie viel Vitamin D3 in die jeweils folgenden Formen umgewandelt wird. 2017;100:1337–44. Guidelines for preventing and treating vitamin D deficiency and insufficiency revisited. Galior K, Ketha H, Grebe S, Singh RJ. 2017;1497:102–9. 2019;4:247–53. 2015;61:877–84. BA, AC and MFH critically revised the article for important intellectual content. 2010. doi:10.1016/j.ecl.2010.02.010. Provided by the Springer Nature SharedIt content-sharing initiative, Journal of Endocrinological Investigation (2023), Analytical and Bioanalytical Chemistry (2023), Analytical and Bioanalytical Chemistry (2022), European Journal of Clinical Nutrition (Eur J Clin Nutr) Ein Vorteil beim Arzt ist definitiv, dass du die Blutabnahme nicht selbst machen musst. myLAB Box offers fast results by including a free 2-day shipping label and provides you with results 2 to 5 days after receiving the sample. Die Kosten für ein Test-Kit liegen bei etwa 30 Euro. Less than 12 ng/mL is considered deficient. Is There a Link Between Vitamin D and Breast Cancer? and JavaScript. Correspondence to Each relies on a finger prick blood sample. Vitamin D. 4th edn. Ähnlich, wie die mittlerweile bekannten Schnelltests für COVID, funktionieren die Vitamin D Schnelltests für zuhause. 2012;45:326–30. Bone. Die Blutentnahme aus der Fingerspitze wird von den meisten Menschen als sehr viel angenehmer empfunden als eine Blutentnahme beim Arzt. The test is also known as the 25-OH vitamin D test and the calcidiol 25-hydroxycholecalciferol test. Annweiler C, Duval G, Launay CP. Hart, Gillian R., et al. Annweiler C, Legrand E, Souberbielle JC. This article explains how to…, Selenium is an important mineral for many body functions. To obtain It isn’t common practice to screen for vitamin D deficiency in otherwise healthy individuals, so it’s ideal to speak with your healthcare professional before trying an at-home test (2). Was ist die beste Option: Blutabnehmen beim Arzt oder Selbsttest zuhause? J Clin Lab Anal. Holmes EW, Garbincius J, McKenna KM. Vitamin D levels are identified based on amounts in your blood, and measured in nanograms per milliliter (ng/mL) or nanomoles per liter (nmol/L). 2012;44:896–9. Vitamin D and its implications for musculoskeletal health in women: an update. Current assays to determine free 25-hydroxyvitamin D in serum. The test can determine whether your vitamin D levels are too high or too low. "Vitamin D concern is something I've seen become increasingly of interest over the last three years in my practice due to the fact so many individuals across the U.S. have low vitamin D levels," Shaw tells Verywell. Candidate reference measurement procedures for serum 25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 by using isotope-dilution liquid chromatography-tandem mass spectrometry. Later, the liver and kidneys convert 25-hydroxyvitamin D (25-OH D) into the biologically active form, 1,25-dihydroxy vitamin D (4). 2017;27:332–41. A study published in August highlighted vitamin D deficiency in COVID-19 patients who experienced acute respiratory failure. An October study on 50 COVID-19 patients linked a high dose of a type of vitamin D (calcifediol) with lower rates of intensive care unit (ICU) treatment.. Hollis BW. Madenci OC, Orcun A, Yildiz Z, Sirmali R, Tuncbilek N, Yucel N, et al. Das Bequeme an einem Schnelltest für Zuhause ist, dass du dir den Weg zum Arzt und die Wartezeit sparst. “Some providers may recommend treating a vitamin level if it is trending down, even before it is in the deficient range, or be able to relate a vitamin deficiency to a certain medication, lifestyle practice, or change in health,” Majumdar, who is also a spokesperson for the Academy of Nutrition and Dietetics, says. Vitamin D Mangel erkennen: Die Top 5 Anzeichen. Oft sind Allgemeinmediziner daher überrascht, wenn Patienten um einen Vitamin-D-Test bitten, oder behaupten sogar, dieser wäre nicht nötig, was irritierend sein kann. 0-12 months. Clin Biochem. aponet.de - Das offizielle Gesundheitsportal der deutschen ApothekerInnen, Vitamin-D-Versorgung könnte Krebssterblichkeit senken, Vitamin-D-Einnahme kann Diabetesrisiko senken, Vitamin D: Nutzen hängt vom Körpergewicht ab, Herzschwäche: Vorsicht mit Eigenbehandlung und Vitaminen, Podcast: Sommer genießen trotz Pollenallergie, Tag der Apotheke: Nachwuchs startet Initiative „Gegen Zukunftsklau“, Fachleute warnen: Vogelgrippevirus verändert sich rasch, Heilpflanzen gegen Husten: Was wirklich hilft. Additionally, research shows vitamin D is important for more than just the health of your muscles and bones.