Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease. Am J Physiol Gastrointest Liver Physiol. 2010 Oct; 16(10):1152-6. 2021 05; 134:105933. 2011 Apr; 25(4):1133-44. NADPH oxidase mediated oxidative stress in hepatic fibrogenesis. J Biol Chem. Systemic infusion of angiotensin II exacerbates liver fibrosis in bile duct-ligated rats. Alcohol Clin Exp Res. Mol Genet Genomic Med. Ezetimibe for the treatment of nonalcoholic steatohepatitis: assessment by novel magnetic resonance imaging and magnetic resonance elastography in a randomized trial (MOZART trial). Microbiome 101: Studying, Analyzing, and Interpreting Gut Microbiome Data for Clinicians. Roles for C16-ceramide and sphingosine 1-phosphate in regulating hepatocyte apoptosis in response to tumor necrosis factor-alpha. J Clin Invest. Gastroenterology. J Clin Invest. Minimizing oxidative stress by gene delivery of superoxide dismutase accelerates regeneration after transplantation of reduced-size livers in the rat. WebMy interests, expertise, and interpersonal skills are backed up by more than 100 scientific publications, prestigious national and international awards, as well as work experience in government laboratories, renowned universities, and leading consulting companies. 2002 Mar; 82(3):323-33. Hepatology. Hepatology. 1996 Sep; 24(3):670-6. Proc Natl Acad Sci U S A. 1989 Aug 11; 17(15):6055-64. To return to the graph. 2016; 7:17. 2014 Dec; 60(6):1920-8. 1995 Oct; 269(4 Pt 1):G591-9. Iwaisako K, Jiang C, Zhang M, Cong M, Moore-Morris TJ, Park TJ, Liu X, Xu J, Wang P, Paik YH, Meng F, Asagiri M, Murray LA. Am J Physiol Gastrointest Liver Physiol. J Clin Exp Hepatol. As a result, the publication counts in this graph might add up to more than the number of publications the person has written. 1993 Feb; 17(2):287-92. J Biol Chem. Cryptochrome mediates circadian regulation of cAMP signaling and hepatic gluconeogenesis. Targeted disruption of the mouse ferrochelatase gene producing an exon 10 deletion. Gastroenterology. 2004 Feb; 126(2):529-40. Am J Physiol Gastrointest Liver Physiol. Methods Mol Biol. 2012 Nov; 67(11):1357-64. Gastroenterology. 2000 Feb; 88(2):142-9. Inhibition of nuclear factor kappaB and phosphatidylinositol 3-kinase/Akt is essential for massive hepatocyte apoptosis induced by tumor necrosis factor alpha in mice. Decreasing fibrogenesis: an immunohistochemical study of paired liver biopsies following lamivudine therapy for chronic hepatitis B. J Hepatol. Placebo-controlled trial of high-dose atorvastatin in patients with severe cerebral small vessel disease. Infiltration of circulating myeloid cells through CD95L contributes to neurodegeneration in mice. Liver Int. Identification of Lineage-Specific Transcription Factors That Prevent Activation of Hepatic Stellate Cells and Promote Fibrosis Resolution. Kagnoff MF, Omary MB, de Grandpre LY, Roebuck KA, Richman DD. Gbele E, Froh M, Arteel GE, Uesugi T, Hellerbrand C, Schlmerich J. Kim YS, Schwabe RF, Qian T, Lemasters JJ. Mol Endocrinol. Integr Biol (Camb). Protection from liver fibrosis by a peroxisome proliferator-activated receptor d agonist. Three distinct cell populations express extracellular matrix proteins and increase in number during skeletal muscle fibrosis. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Alcohol Clin Exp Res. Hepatology. Hatano E, Bradham CA, Stark A, Iimuro Y, Lemasters JJ. Proc Natl Acad Sci U S A. Clin Gastroenterol Hepatol. Westwick JK, Bielawska AE, Dbaibo G, Hannun YA. Type I collagen gene regulation and the molecular pathogenesis of cirrhosis. Cell Metab. Free cholesterol-loaded macrophages are an abundant source of tumor necrosis factor-alpha and interleukin-6: model of NF-kappaB- and map kinase-dependent inflammation in advanced atherosclerosis. Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats. 2020; 15(3):e0229445. Bcker U, Schottelius A, Watson JM, Holt L, Licato LL. Fibrogenesis of parenchymal organs. Download Bio Dr. David Brenner is vice chancellor for health sciencesat the University of CaliforniaSan Diego. In this role, he leads the School of Medicine, Skaggs School of Pharmacy and Pharmaceutical Sciences,Herbert Wertheim SchoolofPublic Healthand Human Longevity Science, and UC San Diego Health. 2013 Mar 01; 3(1):4-11. 2001 Jan; 280(1):G139-48. Roles of AKT and sphingosine kinase in the antiapoptotic effects of bile duct ligation in mouse liver. Scholarship Fund, Molecular Pathogenesis of Apoptosis in Liver Cells, ONCOGENIC K-RAS INDUCTION OF GASTRIN GENE TRANSCRIPTION, GENE TECHNOLOGY THERAPY AND ALCOHOL-INDUCED FIBROSIS, The Southern California Research Center for ALPD and Cirrhosis, Molecular and Cellular Pathogenesis in Alcoholism, MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM, FUNCTION OF NUCLEAR ONCOGENES IN CANCER CELLS, Molecular Mechanisms by which TNFalpha Modulates Fibrosis. Nat Rev Gastroenterol Hepatol. Antiapoptotic effect of c-Jun N-terminal Kinase-1 through Mcl-1 stabilization in TNF-induced hepatocyte apoptosis. J Burn Care Rehabil. 2007 Dec; 133(6):2019-28. La Jolla groups issue letter on city parks master plan. Cox AD, Garcia AM, Westwick JK, Kowalczyk JJ, Lewis MD. Biofactors. 2005 Sep 16; 335(1):87-96. DNase I-hypersensitive sites enhance alpha1(I) collagen gene expression in hepatic stellate cells. An exon 10 deletion in the mouse ferrochelatase gene has a dominant-negative effect and causes mild protoporphyria. 2017 May 02; 25(5):1054-1062.e5. Hepatology. Transcription factors nuclear factor I and Sp1 interact with the murine collagen alpha 1 (I) promoter. 1998 Jul 01; 92(1):320-8. 2014 Aug 12; 111(32):E3297-305. 2004 May 28; 279(22):23822-9. Reif S, Lang A, Lindquist JN, Yata Y, Gabele E, Scanga A. TRAIL-mediated apoptosis requires NF-kappaB inhibition and the mitochondrial permeability transition in human hepatoma cells. 2014 Oct; 27(5):413-25. McArdle PF, Kittner SJ, Ay H, Brown RD, Meschia JF, Rundek T, Wassertheil-Smoller S, Woo D, Andsberg G, Biffi A. Toso regulates differentiation and activation of inflammatory dendritic cells during persistence-prone virus infection. Gut. Contemp Intern Med. Cytokine polymorphisms associated with carotid intima-media thickness in stroke patients. 1993 Jan; 264(1 Pt 1):G95-103. Cellular and molecular biology of hepatocyte growth, regeneration and gene expression. Link between gut-microbiome derived metabolite and shared gene-effects with hepatic steatosis and fibrosis in NAFLD. 2018 09; 68(3):1070-1086. Hepatol Commun. Role of glycogen synthase kinase-3 in TNF-alpha-induced NF-kappaB activation and apoptosis in hepatocytes. Semin Liver Dis. 1997 May; 272(5 Pt 1):G943-53. 2015 Apr 06; 212(4):469-80. Bataller R, Gbele E, Schoonhoven R, Morris T, Lehnert M, Yang L. Toll-like receptor 4 mediates inflammatory signaling by bacterial lipopolysaccharide in human hepatic stellate cells. Rhodes K, Rippe RA, Umezawa A, Nehls M, Brenner DA, Breindl M. PMID: 8065328; PMCID: PMC359121. Gastroenterology. 2003 Apr 15; 170(8):4053-60. J Hepatol. 2016; 7:47. 2012 Jul; 36(1):22-9. J Surg Res. PLoS One. Estrogen increases sensitivity of hepatic Kupffer cells to endotoxin. 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J Biol Chem. Neurogastroenterol Motil. 2018 06; 67(6):2150-2166. Gut. Semin Liver Dis. Liver Transpl. Tumor necrosis factor-alpha inhibits albumin gene expression in a murine model of cachexia. Analysis of the collagen alpha 1(I) promoter. Caussy C, Hsu C, Lo MT, Liu A, Bettencourt R. Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-3p-mediated inhibition of CCR2. 2000 Sep 29; 275(39):30597-604. J Surg Res. 2008 Mar; 23 Suppl 1:S98-103. Modulation of constitutive collagen gene expression by lipid peroxidation. Hellerbrand C, Jobin C, Iimuro Y, Licato L, Sartor RB. 2004 Nov; 40(5):1106-15. Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury. 2013 Apr; 144(4):661-3. Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration. Stefanovic B, Stefanovic L, Schnabl B, Bataller R. Gastrointestinal basic science 2002-2003: the year in review. Inhibition of proinflammatory molecule production by adenovirus-mediated expression of a nuclear factor kappaB super-repressor in human intestinal epithelial cells. 2022 Oct 28; 11(11). J Clin Invest. 1996 Nov; 271(5 Pt 1):G780-90. 2017 Feb 01; 312(2):C131-C143. 2015; 10(7):e0129743. J Mol Med (Berl). 2012 Mar; 27 Suppl 2:65-8. 1994 Dec; 124(6):755-60. Hepatology. Age (Dordr). 2015 May; 31(3):184-91. J Cardiovasc Med (Hagerstown). TNF alpha-induced hepatocyte apoptosis is associated with alterations of the cell cycle and decreased stem loop binding protein. Nucleic Acids Symp Ser. 2006 Aug; 116(8):2058-9. 2008 Aug; 42(5):349-61. Conigliaro A, Amicone L, Costa V, De Santis Puzzonia M, Mancone C, Sacchetti B, Cicchini C, Garibaldi F. Synergistic effects of family history of hepatocellular carcinoma and hepatitis B virus infection on risk for incident hepatocellular carcinoma. 2011 Jul; 41(7):683-6. J Biol Chem. 2018 12; 15(12):785. Xu J, Ma HY, Liang S, Sun M, Karin G, Koyama Y, Hu R. Gastric acid suppression promotes alcoholic liver disease by inducing overgrowth of intestinal Enterococcus. WebDavidBrenner, M.D., a distinguished physician-scientist, is Vice Chancellor for Health Sciences and Dean of the School of Medicine at the University of California, San Diego, effective Inhibition of collagen alpha 1(I) expression by the 5' stem-loop as a molecular decoy. Proc Natl Acad Sci U S A. J Hepatol. Gene Expr. Front Physiol. Fibroblast-specific protein 1 identifies an inflammatory subpopulation of macrophages in the liver. J Hepatol. Brenner succeeds Kristiina Vuori, M.D., Ph.D., who announced her intention to step down as president in January after serving in the role for the past 12 years. Lin A, Frost J, Deng T, Smeal T, al-Alawi N, Kikkawa U, Hunter T. NF-I/Sp1 switch elements regulate collagen alpha 1(I) gene expression. Zhong Z, Schwabe RF, Kai Y, He L, Yang L, Bunzendahl H. NADPH oxidase in the liver: defensive, offensive, or fibrogenic? 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He replaces David A. Brenner as vice chancellor for Health Sciences, who stepped down on July 1, 2022. Awareness, treatment, and control of vascular risk factors among stroke survivors. Ikejima K, Enomoto N, Seabra V, Ikejima A. Gene regulation in hepatic stellate cell. J Biol Chem. Brain Commun. Far upstream regulatory elements enhance position-independent and uterus-specific expression of the murine alpha1(I) collagen promoter in transgenic mice. Mol Cell Biol. 2001; 160:459-79. 2005 Dec; 42(6):1320-8. The renin-angiotensin-aldosterone system in cerebral small vessel disease. 2022 Mar; 1(1):pgac006. Ferrochelatase cDNA delivered by adenoviral vector corrects biochemical defect in protoporphyric cells. Analysis of ferrochelatase expression during hematopoietic development of embryonic stem cells. Therapy for hepatic fibrosis. Gut. 2000 Apr 21; 275(16):11814-23. 2013 Dec; 58(6):1930-40. 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NF-kappaB inactivation converts a hepatocyte cell line TNF-alpha response from proliferation to apoptosis. Neurology. 2021 11; 25(11):2149-2159. Westwick JK, Fleckenstein J, Yin M, Yang SQ, Bradham CA. 2002 Aug; 36(2):315-25. Development of a new, simple rat model of early alcohol-induced liver injury based on sensitization of Kupffer cells. Blood. Akt activation protects rat liver from ischemia/reperfusion injury. Autocrine expression of activated transforming growth factor-beta(1) induces apoptosis in normal rat liver. Taura K, Miura K, Iwaisako K, Osterreicher CH, Kodama Y, Penz-Osterreicher M. Reduction of advanced liver fibrosis by short-term targeted delivery of an angiotensin receptor blocker to hepatic stellate cells in rats. 2008 Feb; 25(2):249-58. 2007 Jun; 22 Suppl 1:S73-8. Nucleic Acids Res. J Clin Invest. 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Hepatic stellate cells primed with cytokines upregulate inflammation in response to peptidoglycan or lipoteichoic acid. J Immunol. 2007 Nov; 46(5):1443-52. Differentiation. Mol Cell Biol. 2014 Jun 10; 20(17):2854-72. Biochem Biophys Res Commun. Nishio T, Iimuro Y, Nitta T, Harada N, Yoshida M, Hirose T, Yamamoto N, Morimoto T. c-Jun-N-terminal kinase drives cyclin D1 expression and proliferation during liver regeneration. Hydrogen peroxide-induced liver cell necrosis is dependent on AP-1 activation. DNA methylation represses the murine alpha 1(I) collagen promoter by an indirect mechanism. 2014 Jul; 124(7):2921-34. Nelson K, Foufoula-Georgiou E, Gelfand M. The role of Mesothelin signaling in Portal Fibroblasts in the pathogenesis of cholestatic liver fibrosis. 2020 Nov 03; 32(5):901. 2015 Feb; 21(2):159-65. 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Parsons CJ, Bradford BU, Pan CQ, Cheung E, Schauer M, Knorr A, Krebs B, Kraft S, Zahn S, Brocks B, Feirt N, Mei B, Cho MS. From quiescence to activation: Gene regulation in hepatic stellate cells. Fuji H, Miller G, Nishio T, Koyama Y, Lam K, Zhang V. CRIg on liver macrophages clears pathobionts and protects against alcoholic liver disease. 2015 Apr 06 ; 1453 ( 1 ): G877-84 Promotes hepatocellular carcinoma a! Of liver fibrosis in rats stroke classification: the NINDS SiGN study: Studying, Analyzing, oligosaccharide. Polymorphisms associated with a mouse model of cachexia, Iimuro Y, Licato L, schnabl B, Purbeck,..., Tugores a, Christensen SR, Wagner-Mcpherson C, hatano E, Bradham,! 335 ( 1 ): G530-8 5 ( Suppl 1 ): S17 is associated with a mouse of! Alcohol-Induced steatohepatitis through bone marrow-derived and endogenous liver cells in mice Licato.! Nishiura T, Bennett BL, Lemasters JJ, Qian T, Nishiura T, Streetz,. 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